Synthesis of Poly-Substituted Quinolines via Friedländer Hetero-Annulation Reaction Using Silica-Supported P2O5 under Solvent-Free Conditions

synthesis of poly-substituted quinolines via friedländer hetero-annulation reaction using silica-supported p2o5 under solvent-free conditions

a highly efficient, simple and green solvent-free protocol for the preparation of poly-substituted quinolines via friedländer hetero-annulation reaction between 2-aminoaryl ketones and carbonyl compounds in the presence of silica-supported p2o5 (p2o5 / sio2) is described. in this method, the title compounds are obtained in high to excellent yields and in short reaction times.

Metal-free aerobic one-pot synthesis of substituted/annulated quinolines from alcohols via indirect Friedländer annulation.

Metal-free, operationally simple, and highly efficient one-pot aerobic process for the synthesis of functionalized/annulated quinolines is devised from easily available 2-aminobenzyl alcohol/2-aminobenzophenones and alkyl/aryl alcohols for the first time. The process involves two sequential reactions, namely in situ aerial oxidation of alcohols to the corresponding aldehydes/ketones followed by...

Fe3O4@SiO2-SO3H as a recyclable heterogeneous nanomagnetic catalyst for the one-pot synthesis of substituted quinolines via Friedländer heteroannulation under solvent-free conditions

An efficient method has been developed for the Friedländer synthesis of substituted quinolines through a condensation reaction of 2-aminoaryl ketones with α-methylene ketones in the presence of a catalytic amount of nano Fe3O4@SiO2-SO3H under solvent-free conditions at 110 °C. The reactions are completed in short times, and the products are obtained in good to excellent yields. The results reve...

Synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions via Phosphorus pentoxide supported on alumina (P2O5/Al2O3) catalyzed tandem reaction of Aldehyde with dimedone

Synthesis of 1,8-dioxo-octahydroxanthenes under solvent-free conditions via Phosphorus pentoxide supported on alumina (P2O5/Al2O3) catalyzed tandem reaction of Aldehyde with dimedone

Phosphorus pentoxide used on alumina (P2O5/Al2O3) as an inexpensive, eco-friendly and non-toxic acid catalyst for the one-pot synthesis of 1,8-dioxo-octahydroxanthenes via multi-component reactions under solvent-free conditions. The present approach offers several advantages such as short reaction times, high yields, easy purification, recovery and reusability of the catalyst.

Synthesis of 4-aryl substituted 3,4-dihydropyrimidinones using silica-chloride under solvent free conditions.

This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free conditions.